Statistical and Computational Genetics
Time: Tuesdays 2:30-3:20pm
Location: Weill Hall 121
Instructor Amy Williams, 102G Weill Hall
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Course description: BTRY 7200 is a graduate seminar on statistical and computational genetics. It has a journal club format in which students, postdocs, and faculty meet to discuss a scientific paper each week. At the beginning of each meeting, one person provides a summary of the paper to be discussed and then all individuals in the class participate in discussion of the paper. Individuals enrolled or participating in this course are expected to present for one week during the term. A list of potential papers for discussion is given below; the presenter has the option of selecting either a paper listed here or can select another paper with permission from the instructor.
Course credit: This course is graded S/U, to receive a satisfactory grade, students must: (1) lead the discussion of a paper on one week and (2) attend class and participate in the discussion.
|February 2||A reference panel of 64,976 haplotypes for genotype imputation.
Shane McCarthy, Sayantan Das, Warren Kretzschmar, et al. bioRxiv, 2015.
|February 9||Estimating the Ages of Selection Signals from Different Epochs in Human History. Shigeki Nakagome, Gorka Alkorta-Aranburu, Roberto Amato, et al. Molecular Biology and Evolution, 2015.||Kaixiong Ye|
|February 23||An Ancestry Based Approach for Detecting Interactions. Danny Park, Itamar Eskin, Eun Yong Kang, Eric R Gamazon, et al. bioRxiv, 2016.||Monica Ramstetter|
|March 1||Genome-wide patterns of selection in 230 ancient Eurasians. Iain Mathieson, Iosif Lazaridis, Nadin Rohland, Swapan Mallick, Nick Patterson, et al. Nature, 2015.||Nathan Oakes|
|March 8||Genotype Imputation with Millions of Reference Samples. Brian L. Browning, Sharon R. Browning. American Journal of Human Genetics, 2016.||Amy Williams|
|March 15||Health and population effects of rare gene knockouts in adult humans with related parents. Vagheesh M. Narasimhan, Karen A. Hunt, Dan Mason, Christopher L. Baker, et al. Science, 2016.||Zachary Stansell|
|March 22||The phenotypic legacy of admixture between modern humans and Neandertals. Corinne N. Simonti, Benjamin Vernot, Lisa Bastarache, Erwin Bottinger, et al. Science, 2016.||Melissa Hubisz|
|April 5||Genome-wide patterns and properties of de novo mutations in humans. Laurent C Francioli, Paz P Polak, Amnon Koren, Androniki Menelaou, et al. Nature Genetics, 2015.||Maryn Carlson|
|April 12||Fast principal components analysis reveals convergent evolution of ADH1B gene in Europe and East Asia. Kevin J Galinsky, Gaurav Bhatia, Po-Ru Loh, Stoyan Georgiev, Sayan Mukherjee, Nick J Patterson, Alkes L Price. AJHG, 2016.||Kaixiong Ye|
|April 19||A Genealogical Look at Shared Ancestry on the X Chromosome. Vince Buffalo, Stephen M. Mount, Graham Coop. bioRxiv, 2016.||Sayantani Basu Roy|
|April 26||Recombination in diverse maize is stable, predictable, and associated with genetic load. Eli Rodgers-Melnick, Peter J. Bradbury, Robert J. Elshire, Jeffrey C. Glaubitz, Charlotte B. Acharya, Sharon E. Mitchell, Chunhui Li, Yongxiang Li, and Edward S. Buckler. PNAS, 2015.||Ariel Chan|
|May 3||Genomic Characterization of Large Heterochromatic Gaps in the Human Genome Assembly. Nicolas Altemose, Karen H. Miga, Mauro Maggioni, Huntington F. Willard. PLOS Comput Biol, 2014.||Mike McGurk|
|May 10||Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.G David Poznik, Yali Xue, Fernando L Mendez, Thomas F Willems, Andrea Massaia, et al. Nature Genetics, 2016.||Stephanie Hilz|