Publications

Preprints

Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Inferring identical by descent sharing of sample ancestors promotes high resolution relative detection. bioRiv, Jan 2018.

Published manuscripts

Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Benchmarking relatedness inference methods with genome-wide data from thousands of relatives. Genetics 207(1):75-82, Sep 2017.

Palmer ND, Goodarzi MO, Langefeld CD, … [22 authors] … Williams AL, … [21 authors] … Watanabe RM, Wagenknecht LE. Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes 64(5):1853-66, May 2015.

Williams AL, Genovese G, Dyer T, et al. for the T2D-GENES Consortium. Non-crossover gene conversions show strong allelic bias and unexpected clustering in humans. eLife 2015;4:e04637, Apr 2015.

The SIGMA Type 2 Diabetes Consortium: Estrada K, Aukrust I, Bjørkhaug L, Burtt NP, Mercader JM, García-Ortiz H, Huerta-Chagoya A, Moreno-Macías H, Walford G, Flannick J, Williams AL*, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA 311(22):2305-14, Jun 2014.
* Preformed sample selection for exome sequencing and contributed to association analyses

The SIGMA Type 2 Diabetes Consortium: Williams AL, Jacobs SBR, Moreno-Macías H, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 506:97-101, Feb 2014.
Led the genetics analysis and wrote the genetics portions of paper.

The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature 491:56-65, Nov 2012.
Developed HAPMIX extension and applied it to the Latino populations.

Williams AL, Patterson N, Glessner J, Hakonarson H, Reich D. Phasing Many Thousands of Genotyped Samples. Am J Hum Genet, 91:238-51, Aug 2012.

Fejerman L, Chen GK, Eng C, Huntsman S, Hu D, Williams A, Pasaniuc B, John EM, Via M, Gignoux C, Ingles S, Monroe KR, Kolonel LN, Torres-Mejía G, Pérez-Stable EJ, Burchard EG, Henderson BE, Haiman CA, Ziv E. Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas. Hum Mol Genet, 21:1907-17, Apr 2012.

Williams AL, Housman DE, Rinard MC, Gifford DK. Rapid Haplotype Inference for Nuclear Families. Genome Biol, 11:R108, Oct 2010.

Williams A, Thies W, Ernst MD. Static Deadlock Detection for Java Libraries. European Conference on Object-Oriented Programming (ECOOP). Glasgow, Scotland, UK. Jul 2005.

Williams A, Barrus S, Morley K, Shirley P. An efficient and robust ray-box intersection algorithm. Journal of Graphics Tools, 10:49-54, Jun 2005.